Does hormone negative,her2 positive need oophorectomy?
Hi, i am breast cancer stage 4 patient. ER- PR- HER2+.. Not done mastectomy yet. Lump is big. I already done first line kimo, FEC 6 cycle. But poor reponse. My oncologist planned for second line chemo along with targetted therapy herceptin.. And she recommend me to do oophorectomy to control the disease. I am lil bit confuse because all this while, I think only hormone positive need to remove ovaries. And then I seek for second opinion. The second doc says there is no need for me to remove ovaries since i am hormone negative. And she ask me to do BRCA1 test before makes a decision. But the date of test is on March. And my second line kimo will finish in early April. So what is doc opinion. Should i just proceed with Oophorectomy without do BRCA1 test or should i done Brca1 test first..
From your description, it appears that you are undergoing treatment for stage 4 breast cancer with ER-negative, PR-negative, and HER2-positive status. Your oncologist has recommended a second-line chemotherapy regimen along with targeted therapy (Herceptin), as well as the possibility of oophorectomy to control the progression of the disease.
Regarding the oophorectomy recommendation, while it is more commonly associated with hormone receptor-positive breast cancers, there may still be clinical reasons for considering this option in HER2-positive breast cancers, even when hormone receptors are negative. Oophorectomy can help reduce the levels of hormones such as estrogen, which can impact the progression of some types of breast cancer. It is also worth noting that some targeted therapies may have additional benefits when combined with ovarian suppression.
As for the BRCA1 genetic test, it is an important test for determining whether you have inherited genetic mutations that could influence the course of your treatment and decisions moving forward. While the BRCA1 test is most often recommended for patients with a family history of breast or ovarian cancer, it can also provide valuable insights into your personal cancer treatment strategy.
Given that your second-line chemotherapy will conclude in early April, we recommend that you proceed with the BRCA1 testing as planned. The results could potentially influence your treatment decisions and provide you with a clearer understanding of your genetic profile. If the results are available before your treatment concludes, they may provide additional guidance to you and your oncologist regarding the necessity and timing of oophorectomy.
It is also important to discuss the timing of these decisions further with your oncologist. They can help ensure that your treatment strategy is aligned with your individual needs and preferences, especially while awaiting the BRCA1 test results.
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